Essentials of pharmaceutical chemistry /
Cairns, Donald.
Essentials of pharmaceutical chemistry / Donald Cairns. - 4th ed. - London ; Chicago : London ; Grayslake, Ill. : Pharmaceutical Press ; imprint of RPS Pub., c2012. - viii, 308 p. : ill. (chiefly col.) ; 24 cm.
Includes bibliographical references and index.
Chemistry of acids and bases -- Dissociation of weak acids and bases -- Hydrolysis of salts -- Amphiprotic salts -- Buffer solutions -- Buffer capacity -- Biological buffers -- Ionisation of drugs -- pK[subscript a] values of drug molecules -- pH indicators -- Partition coefficient and biopharmacy -- Experimental measurement of partition coefficient -- Drug absorption, distribution and bioavailability -- Passive diffusion -- The pH partition hypothesis -- Active transport mechanisms -- The action of local anaesthetics -- Excretion and reabsorption of drugs -- Food and drink -- Physicochemical properties of drugs -- Carboxylic acids -- Phenols -- Warfarin -- Phenylbutazone -- Indometacin -- Barbiturates -- Phenytoin -- Sulfonamides -- Basic drugs -- Basicity of heterocyclic compounds -- Separation of mixtures -- Stereochemistry -- Polarimetry -- Biological systems -- Fischer projections -- Stereochemistry case study: thalidomide -- Geometrical isomerism -- Drug metabolism -- Metabolic pathways -- Cytochromes P450 -- Enzyme induction and inhibition -- Drug conjugation reactions (Phase 2) -- Sterochemistry -- Metabolic pathways for common drugs -- Volumetric analysis of drugs -- Volumetric flask -- Pipette -- Burettes -- Units of concentration -- Concentration of active ingredients -- Design of an assay -- Practical points -- Back and blank titrations -- Assay of unit-dose medicines -- Non-aqueous titrations -- REDOX titrations -- Compleximetric titrations -- Argentimetric titrations -- Limit tests -- Analytical spectroscopy -- Effect of pH on spectra -- Instrumentation -- Experimental measurement of absorbance -- Dilutions -- Quantitative aspects of spectroscopy -- Beer's and Lambert's laws -- Methods of drug assay -- Derivative spectroscopy -- Infrared spectroscopy -- Fluorimetry -- 1. 2. 3. 4. 5. 6. 7.
9780853699798
Pharmaceutical chemistry.
615.19
Essentials of pharmaceutical chemistry / Donald Cairns. - 4th ed. - London ; Chicago : London ; Grayslake, Ill. : Pharmaceutical Press ; imprint of RPS Pub., c2012. - viii, 308 p. : ill. (chiefly col.) ; 24 cm.
Includes bibliographical references and index.
Chemistry of acids and bases -- Dissociation of weak acids and bases -- Hydrolysis of salts -- Amphiprotic salts -- Buffer solutions -- Buffer capacity -- Biological buffers -- Ionisation of drugs -- pK[subscript a] values of drug molecules -- pH indicators -- Partition coefficient and biopharmacy -- Experimental measurement of partition coefficient -- Drug absorption, distribution and bioavailability -- Passive diffusion -- The pH partition hypothesis -- Active transport mechanisms -- The action of local anaesthetics -- Excretion and reabsorption of drugs -- Food and drink -- Physicochemical properties of drugs -- Carboxylic acids -- Phenols -- Warfarin -- Phenylbutazone -- Indometacin -- Barbiturates -- Phenytoin -- Sulfonamides -- Basic drugs -- Basicity of heterocyclic compounds -- Separation of mixtures -- Stereochemistry -- Polarimetry -- Biological systems -- Fischer projections -- Stereochemistry case study: thalidomide -- Geometrical isomerism -- Drug metabolism -- Metabolic pathways -- Cytochromes P450 -- Enzyme induction and inhibition -- Drug conjugation reactions (Phase 2) -- Sterochemistry -- Metabolic pathways for common drugs -- Volumetric analysis of drugs -- Volumetric flask -- Pipette -- Burettes -- Units of concentration -- Concentration of active ingredients -- Design of an assay -- Practical points -- Back and blank titrations -- Assay of unit-dose medicines -- Non-aqueous titrations -- REDOX titrations -- Compleximetric titrations -- Argentimetric titrations -- Limit tests -- Analytical spectroscopy -- Effect of pH on spectra -- Instrumentation -- Experimental measurement of absorbance -- Dilutions -- Quantitative aspects of spectroscopy -- Beer's and Lambert's laws -- Methods of drug assay -- Derivative spectroscopy -- Infrared spectroscopy -- Fluorimetry -- 1. 2. 3. 4. 5. 6. 7.
9780853699798
Pharmaceutical chemistry.
615.19