Comparative pathophysiology and toxicology of cyclooxygenases / (Record no. 12156)
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| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20171224114042.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS--GENERAL INFORMATION | |
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| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
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| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120229s2012 nju ob 001 0 eng d |
| 010 ## - LIBRARY OF CONGRESS CONTROL NUMBER | |
| Canceled/invalid LC control number | 2012002908 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | CDX |
| Language of cataloging | eng |
| Description conventions | pn |
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| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781118351918 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 1118351916 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
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| Qualifying information | (electronic bk.) |
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| International Standard Book Number | 1118351886 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
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| Qualifying information | (electronic bk.) |
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| International Standard Book Number | 1118351908 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 9780470577547 |
| Qualifying information | (Cloth) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 0470577541 |
| Qualifying information | (Cloth) |
| 024 8# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 9786613888525 |
| 028 01 - PUBLISHER NUMBER | |
| Publisher number | EB00063407 |
| Source | Recorded Books |
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| OCLC library identifier | NZ1 |
| System control number | 15915413 |
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| OCLC library identifier | DEBBG |
| System control number | BV043395019 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)808867147 |
| Canceled/invalid control number | (OCoLC)808609679 |
| -- | (OCoLC)809539042 |
| -- | (OCoLC)864910874 |
| -- | (OCoLC)961633114 |
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| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 388852 |
| Source of stock number/acquisition | MIL |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RA1242.D46 |
| Item number | .R33 2012eb |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | WA 671 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 096000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.9/5137 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Radi, Zaher A. |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative pathophysiology and toxicology of cyclooxygenases / |
| Statement of responsibility, etc | Zaher A. Radi. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Hoboken, N.J. : |
| Name of publisher, distributor, etc | Wiley, |
| Date of publication, distribution, etc | ©2012. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource |
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| 380 ## - | |
| -- | Bibliography |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs. |
| 588 0# - | |
| -- | Print version record. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cyclooxygenases |
| General subdivision | Pathophysiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cyclooxygenases |
| General subdivision | Toxicology. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Toxicology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Science. |
| Source of heading or term | fast |
| -- | (OCoLC)fst01108176 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 655 #7 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| Source of term | local |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| International Standard Book Number | 9786613888525 |
| Record control number | (DLC) 2012002908 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://onlinelibrary.wiley.com/book/10.1002/9781118351918">http://onlinelibrary.wiley.com/book/10.1002/9781118351918</a> |
| Public note | Wiley Online Library |
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