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Apicomplexan parasites : molecular approaches toward targeted drug development.

Contributor(s): Wiley InterScience (Online service).
Material type: materialTypeLabelBookSeries: Drug discovery in infectious diseases.Publisher: Weinheim : Chichester : Wiley-VCH ; John Wiley [distributor], 2011Description: pages cm.Content type: text Media type: computer Carrier type: online resourceISBN: 9783527633883; 352763388X.Subject(s): Protozoan vaccines -- Development | ApicomplexaGenre/Form: Electronic books.Additional physical formats: Print version:: Apicomplexan parasites.DDC classification: 615.792 Online resources: Wiley Online Library
Contents:
Front Matter -- Screening, Bioinformatics, Chemoinformatics, and Drug Design. Drug Discovery Approaches toward Anti-Parasitic Agents / Andreas Rohwer, Richard J Marh̲fer, Conor R Caffrey, Paul M Selzer -- New Bioinformatic Strategies against Apicomplexan Parasites / Thomas Dandekar, Ke Xiao -- Sorting Potential Therapeutic Targets in Apicomplexa / Jan A Hiss, Gisbert Schneider -- Alternatives to Drug Development in the Apicomplexa / Theo P M Schetters -- Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches. Energy Metabolism as an Antimalarial Drug Target / Esther Jortzik, Katja Becker -- Polyamines in Apicomplexan Parasites / Ingrid B Muller, Robin Das Gupta, Kai Luersen, Carsten Wrenger, Rolf D Walter -- The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug / Peter Meissner, Heike Adler, Denis Kasozi, Karin Fritz-Wolf, R Heiner Schirmer -- Lipids as Drug Targets for Malaria Therapy / Henri J Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse, Suzanne Peyrottes -- Targeting Apicoplast Pathways in / Snober S Mir, Subir Biswas, Saman Habib -- Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites / Janet Storm, Eva-Maria Patzewitz, Sylke Muller -- Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation / Uday Bandyopadhyay, Sumanta Dey -- Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets / Carsten Wrenger, Ingrid B Muller -- Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein₆Protein Interaction / Ivo Tews, Irmgard Sinning -- Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen / Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling, Boris Striepen, Lizbeth Hedstrom -- Drug Targets in Apicomplexan Parasites. Novel Apicomplexan Phosphatases and Immunophilins as Domain-Specific Drug Targets / Sailen Barik -- Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets / Kathleen Zocher, Stefan Rahlfs, Katja Becker -- Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites / Dominik Kugelstadt, Bianca Derrer, Barbara Kappes -- Protein Acylation: New Potential Targets for Intervention against the Apicomplexa / Joana M Santos, Christian Hedberg, Dominique Soldati-Favre -- Drugs and Drug Targets in and Related Apicomplexans / Joachim Muller, Norbert Muller, Andrew Hemphill -- Compounds. Subversive Substrates of Glutathione Reductases from -Infected Red Blood Cells as Antimalarial Agents / Elisabeth Davioud-Charvet, Don Antoine Lanfranchi -- Ferroquine: A Concealed Weapon / Christophe Biot, Bruno Pradines, Daniel Dive -- Current Aspects of Endoperoxides in Antiparasitic Chemotherapy / Denis Matovu Kasozi, Stefan Rahlfs, Katja Becker -- Hsp90 as an Antimalarial Target / G Sridhar Prasad, Nicholas D P Cosford, Sailen Barik -- Drug Discovery against and / Mohamad Alaa Terkawi, Ikuo Igarashi -- Search for Drugs and Drug Targets against, and () / Sabine Bork-Mimm -- Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? / Christian Miculka, Hon Q Tran, Thorsten Meyer, Anja R Heckeroth, Stefan Baumeister, Frank Seeber, Paul M Selzer -- Recent Drug Discovery against / Jean-Fraṅois Rossignol, J Edward Semple, Andrew V Stachulski, Gilles Gargala.
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Front Matter -- Screening, Bioinformatics, Chemoinformatics, and Drug Design. Drug Discovery Approaches toward Anti-Parasitic Agents / Andreas Rohwer, Richard J Marh̲fer, Conor R Caffrey, Paul M Selzer -- New Bioinformatic Strategies against Apicomplexan Parasites / Thomas Dandekar, Ke Xiao -- Sorting Potential Therapeutic Targets in Apicomplexa / Jan A Hiss, Gisbert Schneider -- Alternatives to Drug Development in the Apicomplexa / Theo P M Schetters -- Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches. Energy Metabolism as an Antimalarial Drug Target / Esther Jortzik, Katja Becker -- Polyamines in Apicomplexan Parasites / Ingrid B Muller, Robin Das Gupta, Kai Luersen, Carsten Wrenger, Rolf D Walter -- The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug / Peter Meissner, Heike Adler, Denis Kasozi, Karin Fritz-Wolf, R Heiner Schirmer -- Lipids as Drug Targets for Malaria Therapy / Henri J Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse, Suzanne Peyrottes -- Targeting Apicoplast Pathways in / Snober S Mir, Subir Biswas, Saman Habib -- Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites / Janet Storm, Eva-Maria Patzewitz, Sylke Muller -- Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation / Uday Bandyopadhyay, Sumanta Dey -- Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets / Carsten Wrenger, Ingrid B Muller -- Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein₆Protein Interaction / Ivo Tews, Irmgard Sinning -- Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen / Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling, Boris Striepen, Lizbeth Hedstrom -- Drug Targets in Apicomplexan Parasites. Novel Apicomplexan Phosphatases and Immunophilins as Domain-Specific Drug Targets / Sailen Barik -- Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets / Kathleen Zocher, Stefan Rahlfs, Katja Becker -- Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites / Dominik Kugelstadt, Bianca Derrer, Barbara Kappes -- Protein Acylation: New Potential Targets for Intervention against the Apicomplexa / Joana M Santos, Christian Hedberg, Dominique Soldati-Favre -- Drugs and Drug Targets in and Related Apicomplexans / Joachim Muller, Norbert Muller, Andrew Hemphill -- Compounds. Subversive Substrates of Glutathione Reductases from -Infected Red Blood Cells as Antimalarial Agents / Elisabeth Davioud-Charvet, Don Antoine Lanfranchi -- Ferroquine: A Concealed Weapon / Christophe Biot, Bruno Pradines, Daniel Dive -- Current Aspects of Endoperoxides in Antiparasitic Chemotherapy / Denis Matovu Kasozi, Stefan Rahlfs, Katja Becker -- Hsp90 as an Antimalarial Target / G Sridhar Prasad, Nicholas D P Cosford, Sailen Barik -- Drug Discovery against and / Mohamad Alaa Terkawi, Ikuo Igarashi -- Search for Drugs and Drug Targets against, and () / Sabine Bork-Mimm -- Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? / Christian Miculka, Hon Q Tran, Thorsten Meyer, Anja R Heckeroth, Stefan Baumeister, Frank Seeber, Paul M Selzer -- Recent Drug Discovery against / Jean-Fraṅois Rossignol, J Edward Semple, Andrew V Stachulski, Gilles Gargala.

Includes bibliographical references and index.

Electronic reproduction. Hoboken, N.J. : Wiley InterScience, 2011. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Mar. 2, 2011). Access may be restricted to users at subscribing institutions.

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