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Applications of transition metal catalysis in drug discovery and development : an industrial perspective / edited by Matthew L. Crawley, Barry M. Trost.

Contributor(s): Crawley, Matthew L | Trost, Barry M.
Material type: materialTypeLabelBookPublisher: Hoboken, N.J. : John Wiley & Sons, ©2012Description: 1 online resource (xviii, 356 pages).Content type: text Media type: computer Carrier type: online resourceISBN: 9781118309872; 1118309871; 9781118309865; 1118309863; 9780470631324; 0470631325; 9781280592386; 1280592389; 9781118309834; 1118309839.Subject(s): Catalysis | Transition metals | Pharmacy | Drug Discovery | Catalysis | Pharmaceutical Preparations -- chemistry | Transition Elements | Medicine | MEDICAL -- Drug Guides | MEDICAL -- Nursing -- Pharmacology | MEDICAL -- Pharmacology | MEDICAL -- Pharmacy | Catalysis | Pharmacy | Transition metalsGenre/Form: Electronic books. | Electronic books.Additional physical formats: Print version:: Applications of Transition Metal Catalysis in Drug Discovery and Development : An Industrial Perspective.DDC classification: 615.1/9 Online resources: Wiley Online Library
Contents:
Applications of TRANSITION METAL CATALYSIS in Drug Discovery and Development; Contents; Preface; Contributors; About the Authors; 1 Transition Metal Catalysis in the Pharmaceutical Industry; 1.1 Overview of Catalysis; 1.2 Transition Metal Catalysis in the Pharmaceutical Industry; 1.2.1 Cross-Couplings for the Formation of Carbon-Carbon Bonds; 1.2.2 Cross-Couplings for the Formation of Carbon-Heteroatom Bonds; 1.2.3 Asymmetric Hydrogenation; 1.2.4 Oxidative Catalysis; 1.2.5 Asymmetric Addition Reactions; 1.2.6 Metathesis; 1.3 Challenges in Taking Catalysis to Industrial Scales.
Summary: "This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development."--Provided by publisher.
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Includes bibliographical references and index.

Applications of TRANSITION METAL CATALYSIS in Drug Discovery and Development; Contents; Preface; Contributors; About the Authors; 1 Transition Metal Catalysis in the Pharmaceutical Industry; 1.1 Overview of Catalysis; 1.2 Transition Metal Catalysis in the Pharmaceutical Industry; 1.2.1 Cross-Couplings for the Formation of Carbon-Carbon Bonds; 1.2.2 Cross-Couplings for the Formation of Carbon-Heteroatom Bonds; 1.2.3 Asymmetric Hydrogenation; 1.2.4 Oxidative Catalysis; 1.2.5 Asymmetric Addition Reactions; 1.2.6 Metathesis; 1.3 Challenges in Taking Catalysis to Industrial Scales.

"This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development."--Provided by publisher.

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