Protein phosphorylation in parasites : novel targets for antiparasitic intervention / edited by Christian Doerig, Gerald Späth and Martin Wiese.

This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who's Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug developmentThe result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second.

Bioinformatics. Computational Analysis of Apicomplexan Kinomes / Eric Talevich, Natarajan Kannan, Diego Miranda-Saavedra -- Phosphatomes of Unicellular Eukaryotic Parasites / Alexandra V Andreeva, Mikhail A Kutuzov -- Functional Analysis of Parasite Kinomes and Phosphatomes. Trypanosomatid Phosphoproteomics / Michael D Urbaniak -- Trypanosomatid Cell Division Kinases / Corinna Benz, Elizabeth Thomas, Tansy C Hammarton -- Kinetoplastid AGC Kinases / Sabine Bachmaier, Michael Boshart -- eIF2[alpha] Kinases / Daniel E Goldberg, Min Zhang, Victor Nussenzweig -- Protein Kinases of the Parasitic Protist / Somlata, Mrigya Babuta, Sudha Bhattacharya, Alok Bhattacharya -- Protein Phosphatases in Trypanosome Growth and Development / Balázs Szöör, Keith R Matthews -- Role of Host Cell Kinomes and Phosphatomes in Parasitic Infections. Hijacking of Host Cell Signaling by / Kerry Woods, Conrad von Schubert, Dirk Dobbelaere -- The Role of Host- and Parasite-Encoded Kinases in -Host Interactions / Ira J Blader, Gustavo Arrizabalaga, William J Sullivan -- Macrophage Kinases in Leishmaniasis / Mahesh Kumar Padwal, Uddipan Sarma, Raki Sudan, Bhaskar Saha -- Drug Discovery. Selective Inhibition of Parasite Protein Kinases / Jennifer D Artz, Amy K Wernimont, Linda Y Lin, Merhnaz Amani, Mirela Neculai, Tanya Hills, Raymond Hui -- Kinase Inhibitors Among Hits from Malaria Cellular Screens / James R Brown, David Drewry, Francisco-Javier Gamo, Jose F Garcia-Bustos -- Calcium-Dependent Protein Kinases of Apicomplexan Parasites as Drug Targets / Kayode K Ojo, Ethan A Merritt, Dustin J Maly, Wesley C Van Voorhis -- Protein Kinases as Suitable Targets for Combating spp / Richard J Marhöfer, Jeremy C Mottram, Paul M Selzer -- Receptor Tyrosine Kinase Signaling and Drug Targeting in Schistosomes / Colette Dissous, Mathieu Vanderstraete, Svenja Beckmann, Nadège Gouignard, Silke Leutner, Christin Buro, Christoph G Grevelding -- Protein Kinases as Drug Targets in the Treatment of Alveolar Echinococcosis / Klaus Brehm -- Collaborative Drug Design of / Barry Hardy, Roman Affentranger, Alessandro Contini, Hugo Gutierrez de Teran, Jeff Spitzner, Ruben Papoian, William L Seibel, Sandra Nelson, Jeffrey Wiseman, Sharon D Bryant, Isabelle Lucet, Christian Doerig.

Includes index.

Print version record.

Includes bibliographical references and index.