Essentials of pharmaceutical chemistry / Donald Cairns.
Material type: TextPublication details: London ; Chicago : Pharmaceutical Press ; London ; Grayslake, Ill. : imprint of RPS Pub., c2012.Edition: 4th edDescription: viii, 308 p. : ill. (chiefly col.) ; 24 cmISBN:- 9780853699798
- 615.19
Item type | Current library | Call number | Copy number | Status | Date due | Barcode | Item holds | |
---|---|---|---|---|---|---|---|---|
Books | Central Library, KUET On Display | 615.19 CAI (Browse shelf(Opens below)) | 01 | Not For Loan | 3010053192 |
Includes bibliographical references and index.
1. Chemistry of acids and bases -- Dissociation of weak acids and bases -- Hydrolysis of salts -- Amphiprotic salts -- Buffer solutions -- Buffer capacity -- Biological buffers -- Ionisation of drugs -- pK[subscript a] values of drug molecules -- pH indicators -- 2. Partition coefficient and biopharmacy -- Experimental measurement of partition coefficient -- Drug absorption, distribution and bioavailability -- Passive diffusion -- The pH partition hypothesis -- Active transport mechanisms -- The action of local anaesthetics -- Excretion and reabsorption of drugs -- Food and drink -- 3. Physicochemical properties of drugs -- Carboxylic acids -- Phenols -- Warfarin -- Phenylbutazone -- Indometacin -- Barbiturates -- Phenytoin -- Sulfonamides -- Basic drugs -- Basicity of heterocyclic compounds -- Separation of mixtures -- 4. Stereochemistry -- Polarimetry -- Biological systems -- Fischer projections -- Stereochemistry case study: thalidomide -- Geometrical isomerism -- 5. Drug metabolism -- Metabolic pathways -- Cytochromes P450 -- Enzyme induction and inhibition -- Drug conjugation reactions (Phase 2) -- Sterochemistry -- Metabolic pathways for common drugs -- 6. Volumetric analysis of drugs -- Volumetric flask -- Pipette -- Burettes -- Units of concentration -- Concentration of active ingredients -- Design of an assay -- Practical points -- Back and blank titrations -- Assay of unit-dose medicines -- Non-aqueous titrations -- REDOX titrations -- Compleximetric titrations -- Argentimetric titrations -- Limit tests -- 7. Analytical spectroscopy -- Effect of pH on spectra -- Instrumentation -- Experimental measurement of absorbance -- Dilutions -- Quantitative aspects of spectroscopy -- Beer's and Lambert's laws -- Methods of drug assay -- Derivative spectroscopy -- Infrared spectroscopy -- Fluorimetry --
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