TY  - BOOK
AU  - Boverhof,Darrell R.
AU  - Gollapudi,B.Bhaskar
TI  - Applications of toxicogenomics in safety evaluation and risk assessment
SN  - 9781118001042
AV  - RA1224.3 .B68 2011eb
U1  - 616/.042 22
PY  - 2011///
CY  - Hoboken, N.J.
PB  - John Wiley & Sons
KW  - Genetic toxicology
KW  - Toxicity testing
KW  - Health risk assessment
KW  - HEALTH & FITNESS
KW  - Diseases
KW  - Genetic
KW  - bisacsh
KW  - MEDICAL
KW  - Genetics
KW  - fast
KW  - Toxicogenetics
KW  - Risk Assessment
KW  - Electronic books
KW  - Electronic resource
KW  - local
N1  - Includes bibliographical references and index; Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach
N2  - "This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher
UR  - http://onlinelibrary.wiley.com/book/10.1002/9781118001042
ER  -