TY  - BOOK
AU  - Cairns,Donald
TI  - Essentials of pharmaceutical chemistry
SN  - 9780853699798
U1  - 615.19 
PY  - 2012///
CY  - London, Chicago, London, Grayslake, Ill.
PB  - Pharmaceutical Press, imprint of RPS Pub.
KW  - Pharmaceutical chemistry
N1  - Includes bibliographical references and index; 1; Chemistry of acids and bases --; Dissociation of weak acids and bases --; Hydrolysis of salts --; Amphiprotic salts --; Buffer solutions --; Buffer capacity --; Biological buffers --; Ionisation of drugs --; pK[subscript a] values of drug molecules --; pH indicators --; 2; Partition coefficient and biopharmacy --; Experimental measurement of partition coefficient --; Drug absorption, distribution and bioavailability --; Passive diffusion --; The pH partition hypothesis --; Active transport mechanisms --; The action of local anaesthetics --; Excretion and reabsorption of drugs --; Food and drink --; 3; Physicochemical properties of drugs --; Carboxylic acids --; Phenols --; Warfarin --; Phenylbutazone --; Indometacin --; Barbiturates --; Phenytoin --; Sulfonamides --; Basic drugs --; Basicity of heterocyclic compounds --; Separation of mixtures --; 4; Stereochemistry --; Polarimetry --; Biological systems --; Fischer projections --; Stereochemistry case study: thalidomide --; Geometrical isomerism --; 5; Drug metabolism --; Metabolic pathways --; Cytochromes P450 --; Enzyme induction and inhibition --; Drug conjugation reactions (Phase 2) --; Sterochemistry --; Metabolic pathways for common drugs --; 6; Volumetric analysis of drugs --; Volumetric flask --; Pipette --; Burettes --; Units of concentration --; Concentration of active ingredients --; Design of an assay --; Practical points --; Back and blank titrations --; Assay of unit-dose medicines --; Non-aqueous titrations --; REDOX titrations --; Compleximetric titrations --; Argentimetric titrations --; Limit tests --; 7; Analytical spectroscopy --; Effect of pH on spectra --; Instrumentation --; Experimental measurement of absorbance --; Dilutions --; Quantitative aspects of spectroscopy --; Beer's and Lambert's laws --; Methods of drug assay --; Derivative spectroscopy --; Infrared spectroscopy --; Fluorimetry --
ER  -