TY  - BOOK
AU  - Stirpe,Fiorenzo
AU  - Lappi,Douglas A.
TI  - Ribosome-inactivating proteins: biology and applications 
SN  - 9781118847015 (ePub)
AV  - QP551 
U1  - 571.6/58 23
PY  - 2014///
CY  - Ames, Iowa
PB  - Wiley
KW  - Proteins
KW  - Synthesis
KW  - Ribosomes
KW  - Structure
KW  - SCIENCE / Life Sciences / Cytology
KW  - bisacsh
KW  - Protein Biosynthesis
KW  - fast
KW  - SCIENCE
KW  - Life Sciences
KW  - Cytology
KW  - Electronic books
N1  - Includes bibliographical references and index; ""Title page""; ""Copyright page""; ""Contributors""; ""Preface""; ""1 Introduction and History""; ""Introduction""; ""Identification and Distribution in Nature""; ""Mechanism of Action""; ""Effects on Cells and Animals""; ""Role in Nature""; ""Practical Applications""; ""Bioweapons""; ""Future Challenges""; ""References""; ""2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily""; ""Introduction""; ""How to Investigate the Distribution of Proteins with an N-glycosidase Domain?""; ""Conclusions""; ""Acknowledgments""; ""Introduction""""Family Sambuceae""; ""Type 2 RIPs from Other families""; ""Uses of nontoxic type 2 RIPs""; ""Concluding remarks""; ""Acknowledgment""; ""References""; ""6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins""; ""Introduction""; ""Cell Surface Events""; ""Endosome to TGN Sorting""; ""From the Golgi to the ER""; ""Reductive Separation and Destabilization of the Holotoxin Subunits""; ""Dislocation Across the ER Membrane""; ""Cytosolic Post-dislocation Events that Restore Catalytic Activity""; ""Concluding Remarks""; ""Acknowledgements""; ""References""; ""7 Shiga Toxins""""Introduction""; ""Purification of Shiga Toxins""; ""Structure and Mechanism of Action of Shiga Toxins""; ""Role of Shiga Toxins in the Pathogenesis of HUS""; ""The 2011 German STEC Outbreak""; ""References""; ""8 The Structure and Action of Ribosome-inactivating Proteins""; ""Introduction""; ""Acknowledgments""; ""References""; ""9 Updated Model of the Molecular Evolution of RIP Genes""; ""Introduction""; ""Important Issues to be Considered in View of the Evolution of RIP Genes""; ""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data""""New Insights in the Overall Phylogeny of Plant RIPs""; ""An Updated Model of the Molecular Evolution of the Plant RIP Gene Family""; ""What is the Evolutionary Link Between Plant and Non-Plant RIPs?""; ""Conclusions""; ""References""; ""10 Enzymology of the Ribosome-inactivating Proteins""; ""Introduction""; ""Ricin as RNA N-glycosidase""; ""Role of SRL in Ribosomes""; ""Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes""; ""Action of RIPs on DNA""
N2  - "This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"--; "Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"--
UR  - http://onlinelibrary.wiley.com/book/10.1002/9781118847237
ER  -