Pharmacogenetics and individualized therapy / edited by Anke-Hilse Maitland-van der Zee, Ann K. Daly.

Includes bibliographical references and index.

Pharmacogenetics : a historical perspective / A.K. Daly -- Pharmacogenetics in drug metabolism : role of phase I enzymes / V. Dolzan -- Pharmacogenetics of phase II drug metabolizing enzymes / I. Cascorbi -- Pharmacogenetics of drug transporters / Henriette E. Meyer zu Schwabedissen, Markus Grube, Heyo K. Kroemer -- Pharmacogenetics of drug targets / M. Arranz and A. Daly -- Cardiovascular pharmacogenetics / Bas J.M. Peters [and others] -- Pharmacogenetics in psychiatry / Evangelia M. Tsapakis [and others] -- Pharmacogenetics in cancer / S. Marsh -- Pharmacogenetics of asthma and COPD / E. Koster [and others] -- Pharmacogenetics of adverse drug reactions / Ann K Daly, Martin Armstrong, and Munir Pirmohamed -- Pharmacogenomics of inflammatory bowel diseaes / Alexander Teml [and others] -- Pharmacogenetics of pain medication / J. Loetsch -- Ethical and social issues in pharmacogenomics testing / S. Vijverberg, T. Pieters, and M. Cornel -- High-throughput genotyping technologies for pharmacogenetics / Beatriz Sobrino and Dr. Angel Carracedo -- Developments in analyses in pharmacogenetic datasets / A. Motsinger -- Applications of pharmacogenetics in pharmaceutical research and development / Daniel K. Burns and Scott S. Sundseth -- Role of pharmacogenetics in registration process / Myong-Jin Kim [and others] -- Pharmacogenetics : possibilities and pitfalls / A.H. Maitland-van der Zee and A.K. Daly.

"Pharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level--and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics."-- Provided by publisher.

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