Ribosome-inactivating proteins : biology and applications / edited by Fiorenzo Stirpe, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Bologna, Italy, Douglas A. Lappi, Advanced Targeting Systems, Inc., San Diego, California, USA.

"This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"-- Provided by publisher.

"Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"-- Provided by publisher.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

""Title page""; ""Copyright page""; ""Contributors""; ""Preface""; ""1 Introduction and History""; ""Introduction""; ""Identification and Distribution in Nature""; ""Mechanism of Action""; ""Effects on Cells and Animals""; ""Role in Nature""; ""Practical Applications""; ""Bioweapons""; ""Future Challenges""; ""References""; ""2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily""; ""Introduction""; ""How to Investigate the Distribution of Proteins with an N-glycosidase Domain?""; ""Conclusions""; ""Acknowledgments""

""Introduction""""Family Sambuceae""; ""Type 2 RIPs from Other families""; ""Uses of nontoxic type 2 RIPs""; ""Concluding remarks""; ""Acknowledgment""; ""References""; ""6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins""; ""Introduction""; ""Cell Surface Events""; ""Endosome to TGN Sorting""; ""From the Golgi to the ER""; ""Reductive Separation and Destabilization of the Holotoxin Subunits""; ""Dislocation Across the ER Membrane""; ""Cytosolic Post-dislocation Events that Restore Catalytic Activity""; ""Concluding Remarks""; ""Acknowledgements""; ""References""

""7 Shiga Toxins""""Introduction""; ""Purification of Shiga Toxins""; ""Structure and Mechanism of Action of Shiga Toxins""; ""Role of Shiga Toxins in the Pathogenesis of HUS""; ""The 2011 German STEC Outbreak""; ""References""; ""8 The Structure and Action of Ribosome-inactivating Proteins""; ""Introduction""; ""Acknowledgments""; ""References""; ""9 Updated Model of the Molecular Evolution of RIP Genes""; ""Introduction""; ""Important Issues to be Considered in View of the Evolution of RIP Genes""

""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data""""New Insights in the Overall Phylogeny of Plant RIPs""; ""An Updated Model of the Molecular Evolution of the Plant RIP Gene Family""; ""What is the Evolutionary Link Between Plant and Non-Plant RIPs?""; ""Conclusions""; ""References""; ""10 Enzymology of the Ribosome-inactivating Proteins""; ""Introduction""; ""Ricin as RNA N-glycosidase""; ""Role of SRL in Ribosomes""; ""Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes""; ""Action of RIPs on DNA""