| 000 | 05886cam a2200853Ka 4500 | ||
|---|---|---|---|
| 001 | ocn696237308 | ||
| 003 | OCoLC | ||
| 005 | 20171224113554.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 110111s2011 njua ob 001 0 eng d | ||
| 010 | _z 2010019505 | ||
| 040 |
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_a9780470910009 _q(electronic bk.) |
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| 020 | _a9780470910016 | ||
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| 020 | _z9780470343425 | ||
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| 024 | 8 | _a9786612888984 | |
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_aRC662.4 _b.M53 2011eb |
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_aWK 820 _bM58695 2011 |
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| 049 | _aMAIN | ||
| 245 | 0 | 0 |
_aMetabolic Syndrome : _bUnderlying Mechanisms and Drug Therapies / _cedited by Minghan Wang. |
| 260 |
_aHoboken, N.J. : _bJohn Wiley & Sons, _c©2011. |
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| 300 |
_a1 online resource (xiii, 494 pages) : _billustrations |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aGut as an endocrine organ : the role of nutrient-sensing in energy metabolism / Minghan Wang -- Central glucose sensing and control of food intake and energy homeostasis / Lourdes Mounien and Bernard Thorens -- Abnormalities in insulin secretion in type 2 diabetes mellitus / Taly Meas and Pierre-Jean Guillausseau -- Adipokine production by adipose tissue : a novel target for treating metabolic syndrome and its sequelae / Vanessa DeClercq [and others] -- Hepatic metabolic dysfunctions in type 2 diabetes : insulin resistance and impaired glucose production and lipid synthesis / Ruojing Yang -- Energy metabolism in skeletal muscle and its link to insulin resistance / Minghan Wang -- Mechanisms and complications of metabolic syndrome / Minghan Wang -- Emerging therapeutic approaches for dyslipidemias associated with high LDL and low HDL / Margrit Schwarz and Jae B. Kim -- Mechanism of action of niacin : implications for atherosclerosis and drug discovery / Devan Marar [and others] -- Current anti-diabetic therapies and mechanisms / Minghan Wang -- GLP-1 biology, signaling mechanisms, physiology, and clinical studies / Remy Burcelin [and others] -- Dipeptidyl peptidase IV inhibitors for treatment of diabetes / C.H.S. McIntosh [and others] -- Sodium glucose co-transporter 2 inhibitors / Margaret Ryan and Serge A. Jabbour -- Fibroblast growth factor 21 as a novel metabolic regulator / Radmila Micanovic, James D. Dunbar, and Alexei Kharitonenkov -- Sirtuins as potential drug targets for metabolic diseases / Qiang Tong -- 11[beta]-hydroxysteroid dehydrogenase type 1 as a therapeutic target for type 2 diabetes / Clarence Hale and David J. St. Jean, Jr. -- Monoclonal antibodies for the treatment of type 2 diabetes : a case study with glucagon receptor blockade / Hai Yan, Wei Gu, and Murielle Veniant-Ellison -- Drug development for metabolic diseases: past, present and future / Minghan Wang. | |
| 588 | 0 | _aPrint version record. | |
| 520 | _aThis book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications. | ||
| 650 | 0 |
_aMetabolic syndrome _xPathophysiology. |
|
| 650 | 0 |
_aMetabolic syndrome _xChemotherapy. |
|
| 650 | 2 |
_aMetabolic Syndrome X _xdrug therapy. |
|
| 650 | 2 |
_aMetabolic Syndrome X _xphysiopathology. |
|
| 650 | 4 |
_aMetabolic syndrome _xChemotherapy. |
|
| 650 | 4 |
_aMetabolic syndrome _xPathophysiology. |
|
| 650 | 7 |
_aMEDICAL _xEndocrinology & Metabolism. _2bisacsh |
|
| 650 | 7 |
_aMEDICAL _xNutrition. _2bisacsh |
|
| 650 | 1 | 7 |
_aStofwisselingsziekten. _2gtt _0(NL-LeOCL)078677408 |
| 650 | 1 | 7 |
_aEndocrinologie. _2gtt _0(NL-LeOCL)078497108 |
| 655 | 4 | _aElectronic books. | |
| 655 | 7 |
_aElektronische boeken. _2gtt _0(NL-LeOCL)303983256 |
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| 655 | 7 |
_aElectronic books. _2local |
|
| 700 | 1 |
_aWang, Minghan, _d1966- |
|
| 776 | 0 | 8 |
_iPrint version: _tMetabolic syndrome. _dHoboken, N.J. : John Wiley & Sons, ©2011 _z9780470343425 _w(DLC) 2010019505 _w(OCoLC)614271402 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9780470910016 _zWiley Online Library |
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