| 000 | 04775cam a2200769Ma 4500 | ||
|---|---|---|---|
| 001 | ocn808867147 | ||
| 003 | OCoLC | ||
| 005 | 20171224114042.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 120229s2012 nju ob 001 0 eng d | ||
| 010 | _z 2012002908 | ||
| 040 |
_aCDX _beng _epn _cCDX _dOCLCO _dIDEBK _dDG1 _dN$T _dE7B _dYDXCP _dOCLCQ _dUKDOC _dOCLCQ _dRECBK _dOCLCQ _dOCLCF _dOCLCQ _dCOO _dOCLCQ _dDEBBG _dAZK _dLOA |
||
| 019 |
_a808609679 _a809539042 _a864910874 _a961633114 _a962651029 _a966109639 |
||
| 020 |
_a9781118351918 _q(electronic bk.) |
||
| 020 |
_a1118351916 _q(electronic bk.) |
||
| 020 |
_a9781118351888 _q(electronic bk.) |
||
| 020 |
_a1118351886 _q(electronic bk.) |
||
| 020 |
_a9781118351901 _q(electronic bk.) |
||
| 020 |
_a1118351908 _q(electronic bk.) |
||
| 020 |
_z9780470577547 _q(Cloth) |
||
| 020 |
_z0470577541 _q(Cloth) |
||
| 024 | 8 | _a9786613888525 | |
| 028 | 0 | 1 |
_aEB00063407 _bRecorded Books |
| 029 | 1 |
_aAU@ _b000050060705 |
|
| 029 | 1 |
_aDEBBG _bBV042795848 |
|
| 029 | 1 |
_aDKDLA _b820120-katalog:000600169 |
|
| 029 | 1 |
_aNZ1 _b15915413 |
|
| 029 | 1 |
_aDEBBG _bBV043395019 |
|
| 035 |
_a(OCoLC)808867147 _z(OCoLC)808609679 _z(OCoLC)809539042 _z(OCoLC)864910874 _z(OCoLC)961633114 _z(OCoLC)962651029 _z(OCoLC)966109639 |
||
| 037 |
_a388852 _bMIL |
||
| 050 | 4 |
_aRA1242.D46 _b.R33 2012eb |
|
| 060 | 4 | _aWA 671 | |
| 072 | 7 |
_aMED _x096000 _2bisacsh |
|
| 082 | 0 | 4 |
_a615.9/5137 _223 |
| 049 | _aMAIN | ||
| 100 | 1 | _aRadi, Zaher A. | |
| 245 | 1 | 0 |
_aComparative pathophysiology and toxicology of cyclooxygenases / _cZaher A. Radi. |
| 260 |
_aHoboken, N.J. : _bWiley, _c©2012. |
||
| 300 | _a1 online resource | ||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 347 |
_adata file _2rda |
||
| 380 | _aBibliography | ||
| 504 | _aIncludes bibliographical references and index. | ||
| 520 | _aThe first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks. Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks. Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover: The pathophysiology of COX inhibition on bone, tendon, and ligament healing, COX inhibitors and renal system pathophysiology and mechanisms of toxicity, The pathophysiologic role of COX inhibition in the ocular system, COX inhibition and the respiratory and cardiovascular systems. The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs. | ||
| 588 | 0 | _aPrint version record. | |
| 650 | 0 |
_aCyclooxygenases _xPathophysiology. |
|
| 650 | 0 |
_aCyclooxygenases _xToxicology. |
|
| 650 | 7 |
_aMEDICAL _xToxicology. _2bisacsh |
|
| 650 | 7 |
_aScience. _2fast _0(OCoLC)fst01108176 |
|
| 655 | 4 | _aElectronic books. | |
| 655 | 7 |
_aElectronic books. _2local |
|
| 776 | 0 | 8 |
_iPrint version: _z9786613888525 _w(DLC) 2012002908 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118351918 _zWiley Online Library |
| 938 |
_a123Library _b123L _n55050 |
||
| 938 |
_aCoutts Information Services _bCOUT _n23288674 _c90.50 GBP |
||
| 938 |
_aebrary _bEBRY _nebr10593207 |
||
| 938 |
_aEBSCOhost _bEBSC _n478595 |
||
| 938 |
_aIngram Digital eBook Collection _bIDEB _n388852 |
||
| 938 |
_aRecorded Books, LLC _bRECE _nrbeEB00063407 |
||
| 938 |
_aYBP Library Services _bYANK _n8582290 |
||
| 938 |
_aYBP Library Services _bYANK _n7598153 |
||
| 938 |
_aYBP Library Services _bYANK _n12672234 |
||
| 994 |
_a92 _bDG1 |
||
| 999 |
_c12156 _d12156 |
||