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020 _a9783527665785
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020 _a9783527665815
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020 _a9783527665792
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020 _z9783527333875
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020 _z9783527333875
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029 1 _aAU@
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035 _a(OCoLC)857365390
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037 _a514275
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050 4 _aQD461
072 7 _aSCI
_x016000
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082 0 4 _a548.478
049 _aMAIN
245 0 0 _aSynthetic methods for biologically active molecules :
_bexploring the potential of bioreductions /
_cedited by Elisabetta Brenna.
264 1 _aWeinheim, Germany :
_bWiley-VCH,
_c2013.
264 4 _c©2014
300 _a1 online resource (xviii, 387 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aOnline resource; title from PDF title page (Wiley, viewed September 24, 2013).
504 _aIncludes bibliographical references and index.
505 0 _aDevelopment of Sustainable Biocatalytic Reduction Processes for Organic Chemists / Roland Wohlgemuth -- Reductases: From Natural Diversity to Established Biocatalysis and to Emerging Enzymatic Activities / Elena Fernández-Álvaro, Pablo Domínguez de María -- Synthetic Strategies Based on C=C Bioreductions for the Preparation of Biologically Active Molecules / Francesco G Gatti, Fabio Parmeggiani, Alessandro Sacchetti -- Synthetic Strategies Based on C=O Bioreductions for the Preparation of Biologically Active Molecules / Aníbal Cuetos, Alba Díaz-Rodríguez, Iván Lavandera -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds / Sabrina Kille, Manfred T Reetz -- Protein Engineering: Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds / Nobuya Itoh, Yoshihide Makino -- Synthetic Applications of Aminotransferases for the Preparation of Biologically Active Molecules / Sachin Pannuri, Sanjay Kamat, Abraham R Mártin-García -- Strategies for Cofactor Regeneration in Biocatalyzed Reductions / Selin Kara, Joerg H Schrittwieser, Frank Hollmann -- Solvent Effects in Bioreductions / Yan Ni, Hui-Lei Yu, Jian-He Xu -- Application of Product Removal (ISPR) Technologies for Implementation and Scale-Up of Biocatalytic Reductions / John M Woodley -- Bioreductions in Multienzymatic One-Pot and Cascade Processes / Daniela Monti, Erica E Ferrandi -- Dynamic Kinetic Resolutions Based on Reduction Processes / Dimitris Kalaitzakis, Ioulia Smonou -- Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients / Gábor Tasnádi, Mélanie Hall.
520 _aThis ready reference focuses on the currently available toolbox of biocatalysed reductions of C=O, C=C and formal C=N double bonds to show which transformations are reliable for use in manufacturing processes and which still require improvements and investigation. Following an introductory chapter, chapters 2-4 present the synthetic strategies which are currently available for the reduction of C=C, C=O and for reductive amination, by means of whole cell catalysts and isolated enzymes.
546 _aText in English.
650 0 _aReduction (Chemistry)
650 0 _aBioactive compounds
_xSynthesis.
650 0 _aEnzymes
_xBiotechnology.
650 0 _aEnzymes
_xIndustrial applications.
650 7 _aSCIENCE
_xPhysics
_xCrystallography.
_2bisacsh
650 7 _aBiochemistry.
_2fast
_0(OCoLC)fst00831961
650 7 _aBiomolecules.
_2fast
_0(OCoLC)fst00832624
655 4 _aElectronic books.
700 1 _aBrenna, Elisabetta.
776 0 8 _iPrint version:
_tSynthetic methods for biologically active molecules.
_dWeinheim : Wiley-VCH, 2013
_z9783527333875
_w(OCoLC)856201927
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527665785
_zWiley Online Library
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