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| 008 | 141015s2015 enk ob 001 0 eng | ||
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_a612.015782 _223 |
| 049 | _aMAIN | ||
| 100 | 1 | _aKhabarov, Vladimir N. | |
| 245 | 1 | 0 |
_aHyaluronic acid : _bpreparation, properties, application in biology and medicine / _cV.N. Khabarov, P. Ya. Boykov and M.A. Selyanin ; translated from the Russian by scientific editor Dr. F. Polyak. |
| 264 | 1 |
_aChichester, West Sussex : _bJohn Wiley & Sons, Ltd., _c2015. |
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| 300 | _a1 online resource. | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 588 | 0 | _aPrint version record and CIP data provided by publisher. | |
| 520 | _aHyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid innature, in particular in the human body. The chapter starts fromthe phylogenesis of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially the role whichhyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical means for assessingquality of the finished product. Chapter 4 discusses the structureand rheological properties of hyaluronic acid considering effectson conformation and biological properties related to molecularweight. In Chapter 5, the physical and chemical methods formodifying the structure of hyaluronan are discussed includingcross-linking using bi-functional reagents, solid-phasemodification and effects of the combined action of high pressuresand shift deformation. The final chapter focuses on the productsderived from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated to vitamins, amino acids andoligo-peptides. The biological roles and medical applications ofthis polysaccharide have been extensively studied and this bookprovides a wealth of scientific data demonstrating the criticalrole of hyaluronic acid and its promise as a multifacetedbio-macromolecule. Approaching hyaluronic acid from multiple angles, this booklinks relationships between its biological functions, structure andphysical'chemical properties. It will be an invaluableresource to researchers, both industrial and academic, involved inall aspects of hyaluronan-based technologies. | ||
| 650 | 0 | _aHyaluronic acid. | |
| 650 | 0 | _aOrganic acids. | |
| 650 | 7 |
_aMEDICAL _xPhysiology. _2bisacsh |
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| 650 | 7 |
_aSCIENCE _xLife Sciences _xHuman Anatomy & Physiology. _2bisacsh |
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| 650 | 7 |
_aHyaluronic acid. _2fast _0(OCoLC)fst00964482 |
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| 650 | 7 |
_aOrganic acids. _2fast _0(OCoLC)fst01047633 |
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| 655 | 4 | _aElectronic books. | |
| 700 | 1 | _aBoykov, Petr Ya. | |
| 700 | 1 | _aSelyanin, Mikhail A. | |
| 776 | 0 | 8 |
_iPrint version: _aKhabarov, V.N. (Vladimir N.). _tHyaluronic acid. _dChichester, West Sussex : John Wiley & Sons, Inc., 2015 _z9781118633793 _w(DLC) 2014038400 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118695920 _zWiley Online Library |
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