000			04743cam a2200637Mi 4500
001			ocn893739321
003			OCoLC
005			20171224114742.0
006			m o d
007			cr cnu|||unuuu
008			141025s2014 gw ob 001 0 eng d
040			_aEBLCP _beng _epn _cEBLCP _dOCLCO _dDG1 _dN$T _dOHI _dOCLCF _dDEBSZ _dOCLCQ _dDEBBG _dOCLCQ
020			_a9783527674183 _q(electronic bk.)
020			_a3527674187 _q(electronic bk.)
020			_a9783527674190 _q(electronic bk.)
020			_a3527674195 _q(electronic bk.)
020			_z9783527674206
020			_z3527674209
029	1		_aCHBIS _b010441715
029	1		_aCHVBK _b334091411
029	1		_aDEBBG _bBV042794227
029	1		_aDEBBG _bBV043397226
029	1		_aDEBSZ _b431801037
029	1		_aNZ1 _b15910036
035			_a(OCoLC)893739321
050		4	_aRA1211
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.9 _223
049			_aMAIN
245	0	0	_aPredictive toxicology : _bfrom vision to reality / _cedited by Friedlieb Pfannkuch and Laura Suter-Dick.
260			_aWeinheim : _bWiley-VCH, _c[2014]
300			_a1 online resource (433 pages).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aMethods and Principles in Medicinal Chemistry ; _vv. 64
588	0		_aPrint version record.
520			_aTailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation.
505	0		_aIntroduction to Predictive Toxicology Tools and Methods / Laura Suter-Dick, Friedlieb Pfannkuch -- Toxicology : Current Approaches and Future Perspectives to Predict Toxic Effects with Computational Tools / Thomas Steger-Hartmann -- Approaches: Data Management : Bioinformatics / Arnd Brandenburg, Hans Gmuender, Timo Wittenberger -- Role of Modeling and Simulation in Toxicology Prediction / Antje-Christine Walz, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, Thierry Lave -- Genomic Applications for Assessing Toxicities of Liver and Kidney Injury / Philip Hewitt, Esther Johann -- Use of Toxicogenomics for Mechanistic Characterization of Hepatocarcinogens in Shorter Term Studies / Heidrun Ellinger-Ziegelbauer -- Discovery and Application of Novel Biomarkers / Timothy W Gant, Emma L Marczylo, Martin O Leonard -- Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology / Tobias Heckel, Laura Suter-Dick -- Biomarkers as Tools for Predictive Safety Assessment: Novel Markers of Drug-Induced Kidney Injury / Angela Mally -- The Use of Renal Cell Culture for Nephrotoxicity Investigations / Anja Wilmes, Paul Jennings -- The Zebrafish Model in Toxicology / Natalie Mesens -- Predictive Method Development: Challenges for Cosmetics and Genotoxicity as a Case Study / Gladys Ouedraogo, Fabrice Nesslany, Sophie Simar, Smail Talahari, Doris Lagache, Eric Vercauteren, Lauren Nakab, Astrid Mayoux, Brigitte Faquet, Nicole Flamand -- Using Pluripotent Stem Cells and Their Progeny as an Model to Assess (Developmental) Neurotoxicity / Lisa Hoelting, Marcel Leist, Luc Stoppini -- Stem Cell-Based Methods for Identifying Developmental Toxicity Potential / Jessica A Palmer, Robert E Burrier, Laura A Egnash, Elizabeth LR Donley -- Immunogenicity of Protein Therapeutics: Risk Assessment and Risk Mitigation / Harald Kropshofer -- Regulatory Aspects / Beatriz Silva Lima.
504			_aIncludes bibliographical references and index.
650		0	_aToxicology.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aToxicology. _2fast _0(OCoLC)fst01153364
655		4	_aElectronic books.
700	1		_aPfannkuch, Friedlieb.
700	1		_aSuter-Dick, Laura.
700	1		_aMannhold, Raimund, _d1948-
700	1		_aKubinyi, Hugo.
700	1		_aFolkers, Gerd.
776	0	8	_iPrint version: _tPredictive Toxicology : From Vision to Reality, Volume 64. _dHoboken : Wiley, ©2014 _z9783527336081
830		0	_aMethods and principles in medicinal chemistry.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527674183 _zWiley Online Library
938			_aEBL - Ebook Library _bEBLB _nEBL1818243
938			_aEBSCOhost _bEBSC _n872452
994			_a92 _bDG1
999			_c13740 _d13740