000			06024cam a2200733Ii 4500
001			ocn900723990
003			OCoLC
005			20171224114824.0
006			m o d
007			cr cnu|||unuuu
008			150126s2015 gw ob 001 0 eng d
040			_aN$T _beng _erda _epn _cN$T _dIDEBK _dN$T _dE7B _dYDXCP _dCOO _dRECBK _dOCLCF _dCUS _dEBLCP _dDEBSZ _dUIU _dDEBBG _dCCO
066			_c(S
019			_a902417600
020			_a9783527684410 _qelectronic bk.
020			_a3527684417 _qelectronic bk.
020			_a9783527684403
020			_a3527684409
020			_z9783527337941
020			_z3527337946
020			_a9781322776422 _qMyiLibrary
020			_a1322776423 _qMyiLibrary
029	1		_aDEBSZ _b43187512X
029	1		_aDEBBG _bBV043397474
035			_a(OCoLC)900723990 _z(OCoLC)902417600
050		4	_aQD415
072		7	_aSCI _x013040 _2bisacsh
082	0	4	_a547/.7 _223
049			_aMAIN
245	0	0	_aBioactive Natural Products : _bChemistry and Biology / _cedited by Goutam Brahmachari.
264		1	_aWeinheim, Germany : _bWiley-VCH, _c2015.
300			_a1 online resource (xxxiv, 507 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
588	0		_aVendor-supplied metadata.
504			_aIncludes bibliographical references and index.
505	0		_aBioactive Natural Products; Contents; Foreword; Preface; About the Editor; List of Contributors; Chapter 1 An Overview; 1.1 Introduction; 1.2 An Overview of the Book; 1.2.1 Chapter 2; 1.2.2 Chapter 3; 1.2.3 Chapter 4; 1.2.4 Chapter 5; 1.2.5 Chapter 6; 1.2.6 Chapter 7; 1.2.7 Chapter 8; 1.2.8 Chapter 9; 1.2.9 Chapter 10; 1.2.10 Chapter 11; 1.2.11 Chapter 12; 1.2.12 Chapter 13; 1.2.13 Chapter 14; 1.2.14 Chapter 15; 1.2.15 Chapter 16; 1.2.16 Chapter 17; 1.3 Concluding Remarks; Chapter 2 Use of Chemical Genomics to Investigate the Mechanism of Action for Inhibitory Bioactive Natural Compounds.
505	8		_a2.1 Introduction: Antibiotic Resistance and the Use of Natural Products as a Source for Novel Antimicrobials2.2 Chemical Genetics and Genomics; 2.3 Development of GDA Technology; 2.3.1 The Use of Gene Deletion Arrays (GDAs) to Investigate MOA; 2.3.2 Chemical Genetic Interactions; 2.3.3 Quantifying Genetic and Chemical Genetic Interactions; 2.3.4 Data Analysis; 2.3.5 Platforms for Chemical Genomic GDA Studies; 2.3.6 Why Screen Natural Products in GDAs?; 2.3.7 Successful Applications of GDA Technology; 2.4 Concluding Remarks; Abbreviations; References.
505	8		_6880-01 _aChapter 4 Immunosuppressants: Remarkable Microbial Products4.1 Introduction; 4.2 Discovery; 4.3 Mode of Action; 4.4 Biosynthesis; 4.4.1 Acetate, Propionate, Butyrate, Methionine, and Valine as Precursors of the Macrolide Rings of Sirolimus, Ascomycin, and Tacrolimus; 4.4.2 Pipecolate Moiety of the Macrolide Ring of Sirolimus, Ascomycin, and Tacrolimus; 4.4.3 The Final Step in Biosynthesis of Ascomycins and Tacrolimus; 4.4.4 Formation of the Substituted Cyclohexyl Moiety of Sirolimus, Tacrolimus, and Ascomycins; 4.4.5 Biosynthesis of Cyclosporin; 4.5 Genetics and Strain Improvement.
505	8		_a4.6 Fermentation and Nutritional Studies4.7 Other Activities of Immunosuppressants; 4.8 Concluding Remarks; Acknowledgments; References; Chapter 5 Activators and Inhibitors of ADAM-10 for Management of Cancer and Alzheimer's Disease; 5.1 Introduction to ADAM Family of Enzymes; 5.2 ADAM-10 Structure and Physiological Roles; 5.3 Pathological Significance; 5.3.1 Modulating ADAM Activity in Neurodegeneration; 5.3.2 ADAM-10 in Cancer Pathology; 5.4 ADAM-10 as Potential Drug Target; 5.5 Synthetic Inhibitors of ADAM-10; 5.6 Natural Products as Activators and Inhibitors for ADAM-10.
520			_aNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural productsFeatures chemi.
650		0	_aNatural products.
650		0	_aBiochemistry.
650		7	_aSCIENCE / Chemistry / Organic _2bisacsh
650		7	_aBiochemistry. _2fast _0(OCoLC)fst00831961
650		7	_aNatural products. _2fast _0(OCoLC)fst01034390
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aBrahmachari, Goutam, _eeditor.
776	0	8	_iPrint version: _aBrahmachari, Goutam. _tBioactive Natural Products : Chemistry and Biology. _dHoboken : Wiley, ©2015 _z9783527337941
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527684403 _zWiley Online Library
880	8		_6505-01/(S _aChapter 3 High-Throughput Drug Screening Based on Cancer Signaling in Natural Product Screening3.1 Introduction; 3.2 Cancer Signaling Pathways with Their Own Drug Screening Assays in HTS; 3.2.1 β-Galactosidase Enzyme Complementation Assays for EGFR Signaling Drug Screening; 3.2.2 Fluorescence Superquenching Assays for PI3Ks Signaling Drug Screening; 3.2.3 TOP Flash Reporter Gene Assays for Wnt Signaling Drug Screening; 3.2.4 Luciferase Reporter Gene Assays for STATs Signaling Drug Screening; 3.3 Concluding Remarks; Abbreviations; References.
938			_aEBL - Ebook Library _bEBLB _nEBL4042558
938			_aEBSCOhost _bEBSC _n942565
938			_aIngram Digital eBook Collection _bIDEB _ncis30551321
938			_aebrary _bEBRY _nebr11011142
938			_aYBP Library Services _bYANK _n12261767
938			_aRecorded Books, LLC _bRECE _nrbeEB00596213
938			_aEBL - Ebook Library _bEBLB _nEBL1896077
938			_aYBP Library Services _bYANK _n11632403
938			_aYBP Library Services _bYANK _n12679644
994			_a92 _bDG1
999			_c13872 _d13872