000			02852nam a2200385Ii 4500
001			CRC0KE13584PDF
003			FlBoTFG
005			20171224123339.0
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007			cr||||
008			130918s2014 flu ob 001 0 eng d
020			_a9781439874509 (ebook : PDF)
040			_aFlBoTFG _beng _cFlBoTFG _erda
090			_aRM170 _b.G74 2014
092			_a615.6 _bG797
100	1		_aGreen, Owen P., _eauthor.
245	1	0	_aNon-clinical vascular infusion technology / _cOwen P. Green, Guy Healing.
264		1	_aBoca Raton : _bTaylor & Francis, _c2014.
300			_a1 online resource : _btext file, PDF
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aVolume 1. The science -- volume 2. The techniques.
520			_a"Preface There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed"--Provided by publisher.
530			_aAlso available in print format.
650		0	_aMedical sciences.
650		0	_aDrugs.
650		0	_aIntravenous therapy.
650		0	_aAnimal models in research.
655		7	_aElectronic books. _2lcsh
700	1		_aHealing, Guy, _d1961- _eauthor.
776	0	8	_iPrint version: _z9781439874493 (hardback : alk. paper)
856	4	0	_uhttp://marc.crcnetbase.com/isbn/9781439874509 _qapplication/PDF _zDistributed by publisher. Purchase or institutional license may be required for access.
999			_c14765 _d14765