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008			110525s2011 fluadf sb 001 0 eng d
020			_a9781439818619 (ebook : PDF)
040			_aFlBoTFG _cFlBoTFG
090			_aQP552.T77 _bT76 2011
092			_a572.696 _bT864
245	0	0	_aTRP channels _h[electronic resource] / _cedited by Michael X. Zhu.
260			_aBoca Raton : _bCRC Press, _c2011.
300			_axxii, 473 p., [4] p. of plates : _bill. (some col.).
490	1		_aMethods in signal transduction
500			_a"A CRC title."
504			_aIncludes bibliographical references and index.
505	0		_ach. 1. High-throughput screening of TRPC channel ligands using cell-based assays / Melissa Miller ... [et al.] -- ch. 2. Methods to study TRPC channel regulation by interacting proteins / Kirill Kiselyov ... [et al.] -- ch. 3. Activation of TRP channels in mammalian systems / Tomohiro Numata ... [et al.] -- ch. 4. Studying subunit interaction and complex assembly of TRP channels / Michael Poteser and Klaus Groschner -- ch. 5. Proteomic analysis of TRPC channels / Timothy Lockwich ... [et al.] -- ch. 6. Lessons of studying TRP channels with antibodies / Marcel Meissner ... [et al.] -- ch. 7. Assessing TRPC channel function using pore-blocking antibodies / Shang-Zhong Xu -- ch. 8. Strategies and protocols to generate mouse models with targeted mutations to analyze TRP channel functions / Marc Freichel ... [et al.] -- ch. 9. Studying endogenous TRP channels in visceral and vascular smooth muscles / Alexander V. Zholos --
505	8		_ach. 10. TRPC channels in neuronal survival / Junbo Huang ... [et al.] -- ch. 11. Electrophysiological methods for the study of TRP channels / Karel Talavera and Bernd Nilius -- ch. 12. High-throughput approaches to studying mechanisms of TRP channel activation / Hongzhen Hu ... [et al.] -- ch. 13. Methods used for studying TRP channel functions in sensory neurons / Louis S. Premkumar -- ch. 14. Time-resolved activation of thermal TRP channels by fast temperature jumps / Feng Qin -- ch. 15. Fluorescence Microscopy in thermoTRP channel research / Fan Yang and Jie Zheng -- ch. 16. Regulation of TRP channels by osmomechanical stress / Min Jin ... [et al.] -- ch. 17. Study of TRP channels in cancer cells / V'yacheslav Lehen'kyi and Natalia Prevarskaya -- ch. 18. In vitro and in vivo assays for the discovery of analgesic drugs targeting TRP channels / Jun Chen ... [et al.] -- ch. 19. Studying TRP channels in intracellular membranes / Mohammad Samie and Haoxing Xu -- ch. 20. Methods for studying Drosophila TRP channels / Elkana Kohn and Baruch Minke -- ch. 21. Studying TRP channels in Caenorhabditis elegans / Rui Xiao and X.Z. Shawn Zu.
520			_a"Transient Receptor Potential (TRP) channels have gained a lot of popularity in recent years due to their involvement in a wide variety of cellular functions in many different systems. The purpose of this book is to provide detailed methods for the study of TRP channels. It includes expression and functional studies of TRP channels in heterologous systems as well as structural and functional studies of TRP channels. The author also explores various methods for detailed analysis of biophysical properties of TRP channels. In addition, the text covers high-throughput screening assays for TRP channels and offers novel and effective approaches to study endogenous TRP channel function in native systems"--Provided by publisher.
530			_aAlso available in print edition.
538			_aMode of access: World Wide Web.
650		0	_aTRP channels.
655		7	_aElectronic books. _2lcsh
700	1		_aZhu, Michael Xi.
776	1		_z9781439818602
830		0	_aMethods in signal transduction.
856	4	0	_uhttp://marc.crcnetbase.com/isbn/9781439818619 _qapplication/PDF _zDistributed by publisher. Purchase or institutional license may be required for access.
999			_c14838 _d14838