000			02660cam a2200241Ia 4500
999			_c16770 _d16770
001			001497544
003			BD-KhUET
005			20180805121531.0
008			180805s2012 enka b 001 0 eng
020			_a9780853699798
040			_aESU _cESU _dBD-KhUET
082			_a615.19
100	1		_aCairns, Donald.
245	1	0	_aEssentials of pharmaceutical chemistry / _cDonald Cairns.
250			_a4th ed.
260			_aLondon ; _aChicago : _bPharmaceutical Press ; _aLondon ; _aGrayslake, Ill. : _bimprint of RPS Pub., _cc2012.
300			_aviii, 308 p. : _bill. (chiefly col.) ; _c24 cm.
504			_aIncludes bibliographical references and index.
505	0	0	_g1. _tChemistry of acids and bases -- _tDissociation of weak acids and bases -- _tHydrolysis of salts -- _tAmphiprotic salts -- _tBuffer solutions -- _tBuffer capacity -- _tBiological buffers -- _tIonisation of drugs -- _tpK[subscript a] values of drug molecules -- _tpH indicators -- _g2. _tPartition coefficient and biopharmacy -- _tExperimental measurement of partition coefficient -- _tDrug absorption, distribution and bioavailability -- _tPassive diffusion -- _tThe pH partition hypothesis -- _tActive transport mechanisms -- _tThe action of local anaesthetics -- _tExcretion and reabsorption of drugs -- _tFood and drink -- _g3. _tPhysicochemical properties of drugs -- _tCarboxylic acids -- _tPhenols -- _tWarfarin -- _tPhenylbutazone -- _tIndometacin -- _tBarbiturates -- _tPhenytoin -- _tSulfonamides -- _tBasic drugs -- _tBasicity of heterocyclic compounds -- _tSeparation of mixtures -- _g4. _tStereochemistry -- _tPolarimetry -- _tBiological systems -- _tFischer projections -- _tStereochemistry case study: thalidomide -- _tGeometrical isomerism -- _g5. _tDrug metabolism -- _tMetabolic pathways -- _tCytochromes P450 -- _tEnzyme induction and inhibition -- _tDrug conjugation reactions (Phase 2) -- _tSterochemistry -- _tMetabolic pathways for common drugs -- _g6. _tVolumetric analysis of drugs -- _tVolumetric flask -- _tPipette -- _tBurettes -- _tUnits of concentration -- _tConcentration of active ingredients -- _tDesign of an assay -- _tPractical points -- _tBack and blank titrations -- _tAssay of unit-dose medicines -- _tNon-aqueous titrations -- _tREDOX titrations -- _tCompleximetric titrations -- _tArgentimetric titrations -- _tLimit tests -- _g7. _tAnalytical spectroscopy -- _tEffect of pH on spectra -- _tInstrumentation -- _tExperimental measurement of absorbance -- _tDilutions -- _tQuantitative aspects of spectroscopy -- _tBeer's and Lambert's laws -- _tMethods of drug assay -- _tDerivative spectroscopy -- _tInfrared spectroscopy -- _tFluorimetry --
650		0	_aPharmaceutical chemistry.
942			_2ddc _cBK